Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Naltrexone is a medication widely used to help individuals reduce their alcohol intake. It works by blocking the brain's opioid receptors, reducing the pleasurable effects of alcohol and, over time, lowering cravings. Unlike abstinence-based treatments, Naltrexone is commonly used within The Sinclair Method (TSM), which allows individuals to continue drinking while gradually reducing their consumption.